Bioengineering

Rashid Bashir
1270 Digital Computer Lab, 1304 West Springfield Avenue
PH: (217) 333-1867
http://bioengineering.illinois.edu

For the Degree of Bachelor of Science in Bioengineering

Bioengineers use tools from biology, chemistry, physics and math to solve engineering problems that arise in biological systems related to biomaterials, biomechanics and prosthetics, tissue engineering, molecular modeling, imaging, bioinformatics, nanomedicine, synthetic biology, and drug delivery. The goal of research and education in bioengineering is to advance fundamental understanding of how human biological systems function, and to develop effective technology-based solutions to the wide spectrum of societal needs in human development and disease diagnosis, treatment, and prevention.

The Bioengineering department (BIOE) aims to graduate students who:

  • Enter into industry jobs in prominent companies as engineers who work in the areas of:
    • Medical device design
    • Manufacturing
    • Quality control
    • Marketing
    • And work toward the advancement of medicine
  • Pursue graduate studies in bioengineering-related fields such as:
    • Imaging and Sensing
    • Therapeutics
    • Tissue Engineering
    • Computational and Systems Biology
    • Biomechanics
  • Broaden their education by attending professional school in areas of medicine, law, and business
  • Maintain professional development through societal memberships and industry workshops

The curriculum includes integration of principles of biology and engineering in coursework such as biomechanics, modeling of human physiology, bioinstrumentation, and cell and tissue engineering. The curriculum is project-based and has a strong emphasis on systems-thinking as an approach to large-scale bioengineering problems. During the first and second years, students take fundamental courses introducing them to bioengineering as a field and introducing clinically relevant projects as learning experiences. The program also features hands-on laboratory courses for real-world experience throughout the curriculum. The final two years allow students to focus on a particular track of Bioengineering for further study. A year-long senior capstone design course provides experience in applying engineering fundamentals to biological problems submitted by faculty, clinicians, and industrial firms.

Overview of Curricular Requirements

The curriculum requires 128 hours for graduation and is organized as shown below.

Technical grade point average requirements for graduation and advanced-level course registration apply to students in this curriculum. These rules are summarized at the College of Engineering's Undergraduate Advising Website.

Orientation and Professional Development

These courses introduce the opportunities and resources your college, department, and curriculum can offer you as you work to achieve your career goals. They also provide the skills to work effectively and successfully in the engineering profession.

BIOE 120Introduction to Bioengineering1
ENG 100Engineering Orientation0
Total Hours1

Foundational Mathematics and Science

These courses stress the basic mathematical and scientific principles upon which the engineering discipline is based.

CHEM 102General Chemistry I3
CHEM 103General Chemistry Lab I1
CHEM 104General Chemistry II3
CHEM 105General Chemistry Lab II1
MATH 221Calculus I 14
MATH 231Calculus II3
MATH 241Calculus III4
MATH 285Intro Differential Equations3
PHYS 211University Physics: Mechanics4
PHYS 212University Physics: Elec & Mag4
Total Hours30
1

MATH 220 may be substituted, with four of the five credit hours applying toward the degree. MATH 220 is appropriate for students with no background in calculus.

Bioengineering Technical Core

These courses stress fundamental concepts and basic laboratory techniques that comprise the common intellectual understanding of bioengineering.

BIOE 201Conservation Principles Bioeng3
BIOE 202Cell & Tissue Engineering Lab2
BIOE 205Signals & Systems in Bioengrg3
BIOE 206Cellular Bioengineering3
BIOE 220Bioenergetics4
BIOE 301Introductory Biomechanics3
BIOE 302Modeling Human Physiology3
BIOE 303Quantitative Physiology Lab2
BIOE 310Comp Tools Bio Data3
BIOE 360Transport & Flow in Bioengrg3
BIOE 414Biomedical Instrumentation3
BIOE 415Biomedical Instrumentation Lab2
BIOE 420Intro Bio Control Systems3
BIOE 435Senior Design I2
BIOE 436Senior Design II2
BIOE 476Tissue Engineering3
CHEM 232Elementary Organic Chemistry I 13
CS 101Intro Computing: Engrg & Sci3
MCB 150Molec & Cellular Basis of Life4
Total Hours54
1

May be taken for 4 credit hours; the extra hour may be used to help meet free elective requirements.

Track Electives

Students must complete 15 hours of study which show coherence, focus, and purpose within a bioengineering context. Students may choose from among the following pre-approved tracks:

  • Biomechanics
  • Cell and Tissue Engineering
  • Computational and Systems Biology
  • Imaging and Sensing
  • Therapeutics Engineering

Alternately a student may devise a special track and set of courses which must be approved by the Bioengineering Department. In either case, overage hours in required courses may be counted toward the 15-hour minimum.

Track electives selected from a departmentally approved list of track elective courses. 115
1

List of track elective courses.

Liberal Education

The liberal education courses develop students’ understanding of human culture and society, build skills of inquiry and critical thinking, and lay a foundation for civic engagement and lifelong learning.

Electives from the campus General Education Social and Behavioral Sciences list. 6
Electives from the campus General Education Humanities and the Arts list.6
Electives either from a list approved by the college, or from the campus General Education lists for Social and Behavioral Sciences or Humanities and the Arts.6
Total Hours18

Students must also complete the campus cultural studies requirement by completing (i) one western/comparative culture(s) course and (ii) one non-western/U.S. minority culture(s) course from the General Education cultural studies lists. Most students select liberal education courses that simultaneously satisfy these cultural studies requirements. Courses from the western and non-western lists that fall into free electives or other categories may also be used satisfy the cultural studies requirements.

Composition

These courses teach fundamentals of expository writing.

RHET 105Writing and Research4
Advanced Composition. May be satisfied by completing a course in either the liberal education or free elective categories which has the Advanced Composition designation.
Total Hours4

Free Electives

These unrestricted electives, subject to certain exceptions as noted at the College of Engineering Advising Website, give the student the opportunity to explore any intellectual area of unique interest. This freedom plays a critical role in helping students to define research specialties or to complete minors.

Free electives. Additional unrestricted course work, subject to certain exceptions as noted at the College of Engineering advising Web site, so that there are at least 128 credit hours earned toward the degree. 6
1

College of Engineering Advising Website.

Suggested Sequence

The schedule that follows is illustrative, showing the typical sequence in which courses would be taken by a student with no college course credit already earned and who intends to graduate in four years. Each individual's case may vary, but the position of required named courses is generally indicative of the order in which they should be taken.

First Year
First SemesterHours
BIOE 120Introduction to Bioengineering1
ENG 100Engineering Orientation0
CHEM 103General Chemistry Lab I1
MATH 2211Calculus I4
RHET 105 or MCB 1502Writing and Research4
Liberal education elective33
CHEM 102General Chemistry I3
 Semester Hours16
Second Semester
MATH 231Calculus II3
CHEM 104General Chemistry II3
MCB 150 or RHET 1052Molec Cellular Basis of Life4
CHEM 105General Chemistry Lab II1
Liberal education elective33
PHYS 211University Physics: Mechanics4
 Semester Hours18
Second Year
First Semester
BIOE 206Cellular Bioengineering3
CS 101Intro Computing: Engrg Sci3
MATH 241Calculus III4
PHYS 212University Physics: Elec Mag4
BIOE 201Conservation Principles Bioeng3
 Semester Hours17
Second Semester
BIOE 202Cell Tissue Engineering Lab2
BIOE 205Signals Systems in Bioengrg3
CHEM 2324Elementary Organic Chemistry I3
MATH 285Intro Differential Equations3
BIOE 220Bioenergetics4
 Semester Hours15
Third Year
First Semester
BIOE 301Introductory Biomechanics3
BIOE 414Biomedical Instrumentation3
BIOE 415Biomedical Instrumentation Lab2
Track elective53
Liberal education elective33
BIOE 360Transport Flow in Bioengrg3
 Semester Hours17
Second Semester
BIOE 302Modeling Human Physiology3
BIOE 303Quantitative Physiology Lab2
BIOE 310Comp Tools Bio Data3
BIOE 476Tissue Engineering3
Track elective53
Liberal education elective33
 Semester Hours17
Fourth Year
First Semester
BIOE 420Intro Bio Control Systems3
BIOE 435Senior Design I2
Track electives56
Liberal education elective33
 Semester Hours14
Second Semester
BIOE 436Senior Design II2
Track elective53
Liberal education elective33
Free electives6
 Semester Hours14
 Total Hours: 128
1

MATH 220 may be substituted, with four of the five credit hours applying toward the degree. MATH 220 is appropriate for students with no background in calculus.

2

RHET 105 may be taken in the first or second semester of the first year as authorized. The alternative is MCB 150.

3

Liberal education electives must include 6 hours of social & behavioral sciences and 6 hours of humanities & the arts course work from the campus General Education lists. The remaining 6 hours may be selected from a list maintained by the college, or additional course work from the campus General Education lists for social & behavioral sciences or humanities & the arts. Students must also complete the campus cultural studies requirement by completing (i) one western/comparative culture(s) course and (ii) one non-western/U.S. minority culture(s) course from the General Education cultural studies lists. Most students select liberal education courses that simultaneously satisfy these cultural studies requirements. Courses from the western and non-western lists that fall into free electives or other categories may also be used satisfy the cultural studies requirements.

4

May be taken for 4 credit hours; the extra hour may be used to help meet free elective requirements.

5

To be selected from a departmentally approved list of track elective courses if a pre-approved track is chosen. Alternately a student may devise a special track which must be approved by the Bioengineering Department.

BIOE Class Schedule

Courses

BIOE 100   Bioengineering Freshman Seminar   credit: 0 Hours.

Seminar surveying a broad range of Bioengineering topics. Approved for S/U grading only. Prerequisite: Bioengineering Freshmen Only.

BIOE 120   Introduction to Bioengineering   credit: 1 Hour.

Lectures and discussions of recent trends in bioengineering; topics typically include biological interaction with ultrasound and microwave radiation, modeling, instrumentation, biomaterials, biomechanics, biological heat and mass transfer, and medical imaging techniques.

BIOE 198   Special Topics   credit: 1 to 3 Hours.

Subject offerings related to Bioengineering intended to augment the Bioengineering curriculum. Offerings will be at the freshman level. See class schedule or course information websites for topics and prerequisites. May be repeated if topics vary. Prerequisite: Majors only.

BIOE 200   Bioengineering Career Immersion   credit: 1 Hour.

This course provides exposure to Bioengineering careers through experiences in medicine, industry, and research. Students will observe professional practices to facilitate problem-based discoveries and technology design. Prerequisite: BIOE 120. Majors only.

BIOE 201   Conservation Principles Bioeng   credit: 3 Hours.

Material, energy, charge, and momentum balances in biological problems. Steady-state and transient conservation equations for mass, energy, charge, and momentum will be derived and applied to mathematically analyze physiological systems using basic mathematical principles, physical laws, stoichiometry, and thermodynamic properties. Prerequisite: CHEM 104, MCB 150, and PHYS 211.

BIOE 202   Cell & Tissue Engineering Lab   credit: 2 Hours.

Principles of cell biology inherent in tissue engineering design. Lab experience in safely and skillfully manipulating cells of the four tissue types and performing various quantitative analyses on products produced by cells that have differentiated. Prerequisite: MCB 150, and credit or concurrent enrollment in BIOE 206.

BIOE 205   Signals & Systems in Bioengrg   credit: 3 Hours.

Introduction to signals and linear systems with examples from biology and medicine. Linear systems and mathematical models of systems, including differential equations, convolution, Laplace transforms, Fourier series and transforms, and discrete representations. Class examples and coursework apply general techniques to problems in biological signal analysis, including circuits, enzyme kinematics, and physiological system analysis. Use of Matlab and Simulink software to understand more complex systems. Prerequisite: CS 101, MATH 285, and PHYS 212.

BIOE 206   Cellular Bioengineering   credit: 3 Hours.

Molecular and cellular biology focusing on instrumentation and measurement techniques: gene expression, translation, and regulation; cellular energetics and enzyme kinetics; membrane transport and cell signaling; cytoskeleton and the cell cycle; cell biology fundamentals emphasizing modern imaging and measurement systems to quantify cellular function. Credit is not given for both BIOE 206 and MCB 252. Prerequisite: MCB 150.

BIOE 220   Bioenergetics   credit: 4 Hours.

An integrative view of functional organization and energy transfer in biological systems. Emphasis on dynamics and kinetics of quantum, sub-molecular, and molecular interactions for metabolism. Topics include biomolecules of life, laws of thermodynamics, enzyme kinetics, protein-ligand binding, DNA binding, and modeling of molecular systems. Credit is not given for both BIOE 220 and ME 300, PHYS 214, or CHBE 321. Prerequisites: BIOE 201 and BIOE 206.

BIOE 297   Individual Study   credit: 1 to 4 Hours.

Special project or reading activity. May be repeated in the same or separate terms to a maximum of 12 hours. Prerequisite: Approved written application to department as specified by department or instructor.

BIOE 298   Special Topics   credit: 0 to 4 Hours.

Subject offerings of new and developing areas of knowledge in bioengineering intended to augment the existing curriculum. See Class Schedule or departmental course information for topics and prerequisites. May be repeated in the same or separate terms if topics vary to a maximum of 8 hours.

BIOE 301   Introductory Biomechanics   credit: 3 Hours.

Structure and mechanics of biological systems. Statics, dynamics, stress-strain analysis, Newtonian mechanics, and continuum mechanics. Applications to bone, soft tissue, and cells. Prerequisite: PHYS 211.

BIOE 302   Modeling Human Physiology   credit: 3 Hours.

Description, quantification, and modeling of human physiological systems, based on systems fundamentals. Components, relationships, and homeostatic controls of neural, musculoskeletal, respiratory, cardiovascular, endocrine, digestion, and renal-filtration systems. Application of mathematical modeling and MATLAB simulation to further understanding of the systems and relate physiological consequences to changes in environment or component function. Prerequisite: CS 101, BIOE 205, MATH 285, and MCB 252 or BIOE 206.

BIOE 303   Quantitative Physiology Lab   credit: 2 Hours.

Experiments involving the modeling and measurement of animal and human physiology systems. Use of computer simulations to provide mathematical descriptions of physiology behavior. Calibration and validation of models through hands-on experiments. Focus on quantitative measurement of neural, cardiovascular, respiratory, muscular, and endocrine system functions. Prerequisite: BIOE 302.

BIOE 306   Biofabrication Lab   credit: 3 Hours.

Experiments involving design of bioreactors and microfluidic systems, advanced cell culture, and quantitative analysis techniques such as polmerase chain reaction and atomic force microscopy. Laboratory techniques relating to current literature and state of the art in the field of bioengineering. Prerequisite: BIOE 202. Departmental approval required for non-majors.

BIOE 310   Comp Tools Bio Data   credit: 3 Hours.

Fundamental and applied statistics, including probability distributions, parameter estimation, descriptive statistics, hypothesis testing, and linear regression. Statistical methods in genomics including sequence analysis, gene expression data analysis, human genomic variation, regulatory genomics, and cancer genomics. Credit is not given for both BIOE 310 and IE 300. Prerequisites: BIOE 205 and BIOE 206.

BIOE 360   Transport & Flow in Bioengrg   credit: 3 Hours.

Fundamentals of fluid dynamics and mass transport applied to analysis of biological systems. Quantitative understanding of microscopic to macroscopic phenomena in biological systems related to their sensing by imaging techniques. Molecular phenomena in both healthy tissue and disease using examples from cardiovascular problems and cancer using ultrasound, optical and MRI techniques. Credit is not given for both BIOE 360 and any of CHBE 421, CHBE 451, or TAM 335. Prerequisites: BIOE 201 and BIOE 301.

BIOE 397   Individual Study   credit: 1 to 4 Hours.

Special project or reading activity. May be repeated up to 8 hours in a term to a maximum of 12 total hours. Prerequisite: Approved written application to department as specified by department or instructor.

BIOE 398   Special Topics   credit: 1 to 4 Hours.

Subject offerings of new and developing areas of knowledge in bioengineering intended to augment the existing curriculum. See Class Schedule or departmental course information for topics and prerequisites. May be repeated in the same or separate terms if topics vary to a maximum of 8 hours.

BIOE 410   Computational Cancer Biology   credit: 3 Hours.

Mathematical modeling of the process of carcinogenesis as somatic cell evolution. Focus on current research topics in cancer biology using data from next-generation sequencing technologies. Overview of database resources and algorithmic and modeling methods relating to biological problems. 3 undergraduate hours. No graduate credit. Prerequisite: BIOE 206, CS 101, MATH 285.

BIOE 414   Biomedical Instrumentation   credit: 3 Hours.

Engineering aspects of the detection, acquisition, processing, and display of signals from living systems; biomedical sensors for measurements of biopotentials, ions and gases in aqueous solution, force, displacement, blood pressure, blood flow, heart sounds, respiration, and temperature; therapeutic and prosthetic devices; medical imaging instrumentation. Same as ECE 414. 3 undergraduate hours. 3 graduate hours. Prerequisite: BIOE 205, ECE 205 or ECE 210.

BIOE 415   Biomedical Instrumentation Lab   credit: 2 Hours.

Laboratory to accompany BIOE 414. use of sensors and medical instrumentation for static and dynamic biological inputs. Measurement of biomedical signals. 2 undergraduate hours. 2 graduate hours. Same as ECE 415. Prerequisite: Credit or concurrent registration in BIOE 414.

BIOE 420   Intro Bio Control Systems   credit: 3 Hours.

Systems engineering approach to modeling physiological systems to examine natural biological control systems, homeostasis, and control through eternal medical devices. Introduces open loop and closed loop feedback control; Laplace and Fourier analysis of system behavior; impulse and steady state responses; physiological modeling and system identification; and stability. Includes biological systems for endocrine function, muscle position, neuronal circuits, and cardiovascular function. Mathematical modeling, Matlab and Simulink simulation, and physiological measurements to relate control systems to maintenance of internal environment. 3 undergraduate hours. No graduate credit. Credit is not given for BIOE 420 if credit for AE 353, ECE 486, GE 320, or ME 340 has been earned. Prerequisites: BIOE 205, BIOE 302, BIOE 303, BIOE 414, BIOE 415.

BIOE 430   Intro Synthetic Biology   credit: 3 or 4 Hours.

Introduction to the field of synthetic biology. Engineering applications of biomolecular systems and cellular capabilities for a variety of application biological background of gene regulation, experimental methods for circuit engineering, and mathematical basis for circuit modeling. Examples in biofuels, biomedicine, and other areas will be discussed. 3 undergraduate hours. 4 graduate hours. Prerequisite: BIOE 206 or MCB 252; and MATH 285.

BIOE 435   Senior Design I   credit: 2 Hours.

Capstone bioengineering design activity to develop solutions to projects provided by academia, industry, or clinical settings, utilizing principles of design, engineering analysis, and functional operation of engineering systems. Concept-design, safety, human-factors, quality, and Six-Sigma considerations. Initial solution proposals meeting professional technical-writing and communication standards. Concluded in BIOE 436. 2 undergraduate hours. No graduate credit. Prerequisite: BIOE 301, BIOE 414, and BIOE 415.

BIOE 436   Senior Design II   credit: 2 Hours.

Continuation of BIOE 435. Design teams finalize concepts, evaluate alternatives, model and analyze solutions, build and test a final product, and present the results professionally to project sponsors. 2 undergraduate hours. No graduate credit. Prerequisite: BIOE 435.

BIOE 476   Tissue Engineering   credit: 3 Hours.

Tissue engineering therapies for cell-based, material-based, and therapeutic-based solutions. Stem cells, immunology, and clinical applications. 3 undergraduate hours. 3 graduate hours. Prerequisite: BIOE 301.

BIOE 479   Cancer Nanotechnology   credit: 3 Hours.

Applications in Cancer and Mechanobiology will provide an introduction to basic concepts in applications of nanotechnology in mechanobiology and in cancer. This is a highly interdisciplinary field of research where knowledge from various discipline need to be presented and integrated. The course will be a team taught course by faculty from Engineering and LAS. There will be 4 main sections of the course; (i) biological concepts and cancer biology, (ii) introduction to bottom nanotechnology and nanomedicine, (iii) Microfluidics, Lab on Chip, and Top Down Nanotechnology, and (iv) applications in cellular mechanics, i.e. mechanobiology and nanotechnology. The course will be targeted for first year graduate students and senior undergraduate students. 3 undergraduate hours. 3 graduate hours. Approved for letter and S/U grading. Prerequisite: BIOE 206, CHEM 232.

BIOE 497   Individual Study   credit: 1 to 4 Hours.

Special project or reading activity. 1 to 4 undergraduate hours. 1 to 4 graduate hours. May be repeated up to 8 hours in a term to a maximum of 12 total hours. Prerequisite: Approved written application to department as specified by department or instructor.

BIOE 498   Special Topics   credit: 1 to 4 Hours.

Subject offerings of new and developing areas of knowledge in bioengineering intended to augment the existing curriculum. See Class Schedule or departmental course information for topics and prerequisites. 1 to 4 undergraduate hours. 1 to 4 graduate hours. May be repeated in the same or separate terms if topics vary to a maximum of 12 hours, but no more than 8 in any one term.

BIOE 499   Senior Thesis   credit: 1 to 5 Hours.

Limited in general to seniors in the curriculum in bioengineering. Any others must have the consent of the head of the department. Each student taking the course must register in a minimum of 5 hours either in one term or divided over two terms. A maximum registration of 10 hours in two terms is permitted. 1 to 5 undergraduate hours. No graduate credit. May be repeated, if topics vary. Prerequisite: Majors only, senior standing.