Molecular and Cell Biology (MCB)

MCB Class Schedule

Courses

MCB 100   Introductory Microbiology   credit: 3 Hours.

Introduction to the principal activities and properties of microorganisms, including bacteria, yeasts, molds, and viruses; consideration of the role of natural processes, such as photosynthesis; and man's use and control of microorganisms in the production of antibodies and vaccines in industrial fermentations, in sanitation and public health, and in agriculture. Credit is not given for both MCB 100 and MCB 300. Prerequisite: There are no prerequisites for MCB 100, but some chemistry is recommended.
This course satisfies the General Education Criteria for:
UIUC: Life Sciences

MCB 101   Intro Microbiology Laboratory   credit: 2 Hours.

Laboratory introduction to the techniques employed in the investigation of microbial activities and properties; experiments designed to familiarize the student with the handling, identification, and characterization of microorganisms and their activities, particularly those of interest to man. Credit is not given for both MCB 101 and MCB 301. Prerequisite: Credit or concurrent registration in MCB 100.

MCB 150   Molec & Cellular Basis of Life   credit: 4 Hours.

Introductory course focusing on the basic structure, metabolic, and molecular processes (including membranes, energy metabolism, genes) common to all cells. Emphasis on unique properties that differentiate the major sub-groups of organisms (Archaea, Bacteria, plants, and animals), and will discuss how cells are integrated into tissues and organs in multicellular organisms.
This course satisfies the General Education Criteria for:
UIUC: Life Sciences

MCB 151   Molec & Cellular Laboratory   credit: 1 Hour.

Introductory laboratory course focusing on basic techniques in molecular and cellular biology. Credit is not given for MCB 151 for students majoring in Molecular and Cellular Biology, or Integrative Biology; Credit is not given for both MCB 151 and MCB 251. Prerequisite: Concurrent enrollment in MCB 150.

MCB 170   Society and the Brain   credit: 3 Hours.

Presents recent findings concerning the brain-society interaction. The facts will span many levels, from molecular and cellular interactions, to the functions of specific brain regions, and on to the behaviors of individuals, groups and societies. Intended to bring a broad range of neurobiological data and ideas into an interesting and relevant context.
This course satisfies the General Education Criteria for:
UIUC: Life Sciences

MCB 180   Human Reproduction & Society   credit: 3 Hours.

Lectures and discussions on topics in human reproduction where technological and clinical advances are having economic, social, and ethical consequences.
This course satisfies the General Education Criteria for:
UIUC: Life Sciences

MCB 198   Internship   credit: 0 Hours.

Full-time or part-time internship at another University or an off-campus medical facility, research institute or other approved institution. Approved for S/U grading only. May be repeated. Prerequisite: For MCB and Biochemistry majors only.

MCB 199   Undergraduate Open Seminar   credit: 1 to 5 Hours.

Approved for letter and S/U grading. May be repeated to a maximum of 10 hours.

MCB 215   Foundation in Mol & Cell Bio   credit: 3 Hours.

Online course that will provide transfer students with the essential bases in Molecular and Cellular Biology needed to succeed in the MCB core curriculum, when entering it at the sophomore level. Students will be exposed to the major concepts and the experimental aspects of MCB and be presented with an integrated view of a cell and its inner workings. In addition, a strong peer mentoring program will help students transitioning from their previous institutions by introducing them to the complex setting of a large undergraduate campus. Prerequisite: Successful completion of two semesters of college biology. Credit or concurrent enrollment in CHEM 101, CHEM 102, or equivalent, or consent of instructor.

MCB 244   Human Anatomy & Physiology I   credit: 3 Hours.

Organ system biology with an emphasis on normal human anatomy and physiology, physiological processes and associated disease processes of the following systems; skeletal, muscle, nervous, sensory, and endocrine. Prerequisite: Credit or concurrent enrollment in CHEM 101, CHEM 102, or equivalent; or consent of instructor.

MCB 245   Human Anat & Physiol Lab I   credit: 2 Hours.

Laboratory exploration of normal human anatomy and physiology and relevant disease processes for the following systems: tissue, skeletal, nervous, muscular, sensory, and endocrine. Previously dissected human cadavers are an important part of the learning experience in this course, but students will not dissect human cadavers. Neither animal dissection or animal use are elements of this course. Prerequisite: Credit or concurrent enrollment in CHEM 101, CHEM 102, or equivalent; or consent of instructor.

MCB 246   Human Anatomy & Physiology II   credit: 3 Hours.

Organ system biology with an emphasis on normal human anatomy and physiology, physiological processes and associated disease processes of the following systems: digestion, cardiovascular, respiratory, renal, and reproductive. Prerequisite: MCB 244 and credit or concurrent enrollment in CHEM 101, CHEM 102, or equivalent or consent of instructor.

MCB 247   Human Anat & Physiol Lab II   credit: 2 Hours.

Laboratory exploration of normal human anatomy and physiology and relevant disease processes for the following systems: digestive, cardiovascular, respiratory, renal, and reproductive. Previously dissected human cadavers are an important part of the learning experience in this course, but students will not dissect human cadavers. Neither animal dissection or animal use are elements of this course. Prerequisite: MCB 245 and credit or concurrent enrollment in CHEM 101, CHEM 102, or equivalent; or consent of instructor.

MCB 250   Molecular Genetics   credit: 3 Hours.

Fundamentals of molecular biology including structure of DNA, RNA and proteins, mechanisms of DNA replication, transcription and translation, gene organization, genetic variation and repair, and regulation of gene expression in Bacteria, and Eukarya. Students who enter the University Fall 2011 or later are responsible for additional course-based tuition of $300 unless they are already paying differential tuition during the term of course enrollment. Additional fees may apply. See Class Schedule. Prerequisite: MCB 150, CHEM 102 and CHEM 104, or equivalents or consent of instructor.

MCB 251   Exp Techniqs in Molecular Biol   credit: 2 Hours.

Laboratory course emphasizing a range of molecular biology questions, and the experimental approaches and methodologies needed to answer these questions. Lectures will accompany labs to explain theoretical background and experimental rationale. Students who enter the University Fall 2011 or later are responsible for additional course-based tuition of $300 unless they are already paying differential tuition during the term of course enrollment. Additional fees may apply. See Class Schedule. Credit is not given for both MCB 251 and MCB 151. Prerequisite: Concurrent or prior enrollment in MCB 250 or consent of instructor.

MCB 252   Cells, Tissues & Development   credit: 3 Hours.

Functional organization and physiology of cells and tissues, including cellular signaling, cellular interactions, and developmental processes. Students who enter the University Fall 2011 or later are responsible for additional course-based tuition of $300 unless they are already paying differential tuition during the term of course enrollment. Additional fees may apply. See Class Schedule. Prerequisite: MCB 250 or equivalent with consent of instructor.

MCB 253   Exp Techniqs in Cellular Biol   credit: 2 Hours.

Laboratory course emphasizing experimental techniques in cellular biology, cellular physiology, and developmental biology. Students who enter the University Fall 2011 or later are responsible for additional course-based tuition of $300 unless they are already paying differential tuition during the term of course enrollment. Additional fees may apply. See Class Schedule. Credit is not given for both MCB 253 and MCB 151. Prerequisite: Concurrent or prior enrollment in MCB 252 or consent of instructor.

MCB 270   Medical Genetics   credit: 3 Hours.

Addresses key issues in medical genetics, defined as human genetics for pre-health care professionals. The course covers basic principles of medical ethics, modes of inheritance, the molecular basis of genetic disorders, treatment approaches, gene therapy and emerging technologies like whole genome sequencing. Prerequisite: MCB 252 or equivalent or consent of instructor.

MCB 290   Undergraduate Research   credit: 1 to 5 Hours.

Students assist in and /or conduct research under faculty supervision in an MCB research laboratory. The topics and nature of the work will vary but will be defined as work conducted in MCB research laboratories. For each hour of course credit in fall and spring terms, the student will be expected to complete 5 hours of work in the lab as directed. 75-80 total hours would be the expectation for 1 credit hour during 15-16 week terms. May be repeated to a maximum of 10 hours. Prerequisite: Consent of instructor.

MCB 291   Undergraduate Research Abroad   credit: 1 to 5 Hours.

Students engage in research under faculty supervision at a location outside of the United States. Topics and precise nature of assistance to be determined by MCB faculty in consultation with faculty at the institution. May be repeated in separate terms up to 10 hours. Prerequisite: Consent of MCB faculty who has approved the proposed research plan; consent of faculty member at institution abroad who will be supervising the work and has approved the proposed research plan; evidence of adequate preparation for such study; consent of School of MCB. Not available to freshman.

MCB 297   MCB Honors Discussion   credit: 1 Hour.

Honors discussion section associated with MCB 250, MCB 252, and MCB 354. Concurrent enrollment in the appropriate lecture course is required. May be repeated in separate terms to a maximum of 3 hours.

MCB 298   MCB Honors Lab Discussion   credit: 1 Hour.

Discussion section associated with the Honors lab sections of MCB 251 and MCB 253. Concurrent enrollment in the appropriate Honors lab section is required. May be repeated in separate terms to a maximum of 2 hours.

MCB 299   MCB Merit Program Discussion   credit: 1 Hour.

Provides the extra earned credit hours for students enrolled in the Merit Program in MCB 250, MCB 252, or MCB 354. Approved for letter and S/U grading. May be repeated up to 6 hours in a semester, to a maximum of 10 total hours. Prerequisite: Consent of instructor.

MCB 300   Microbiology   credit: 3 Hours.

Emphasizes fundamental concepts of microbiology, including nutrition, physiology, genetics, molecular biology, ecology and evolution of microorganisms, and their role in nature, human health and disease. Credit is not given for both MCB 300 and MCB 100. Prerequisite: MCB 250 and credit or concurrent registration in MCB 252 or consent of instructor.

MCB 301   Experimental Microbiology   credit: 3 Hours.

Laboratory emphasizing the fundamentals of microbiology. Topics include growth, isolation, and identification of bacteria; restriction endonuclease analysis of DNA, genetic cloning, and gene transfer. Computer methods are used for the identification of microorganisms and for the analysis of recombinant DNA molecules. Prerequisite: MCB 250 and 251 and credit or concurrent registration in MCB 300, or consent of instructor.

MCB 314   Introduction to Neurobiology   credit: 3 Hours.

Introduction to functional and organizational principles of the mammalian nervous system. Topics include the function of nerve cells, neural signaling, sensory and motor systems, learning and memory, attention, motivation, emotions, language, neural development and neurological disorders. A general introduction appropriate for all majors. Same as NEUR 314. Prerequisite: Junior or senior standing.

MCB 316   Genetics and Disease   credit: 4 Hours.

Introduction of the structure, expression, and regulation of genes of higher eukaryotes with an emphasis upon animal cells. Specific topics will include chromatin structure and its relation to gene expression, regulation of gene expression during development, recombination, molecular genetic technologies, gene replacement therapy, and the molecular genetics of cancers. Credit is not given for both MCB 316 and MCB 317. Prerequisite: MCB 150 and credit or concurrent registration in MCB 250 or consent of instructor.

MCB 317   Genetics and Genomics   credit: 4 Hours.

Study of genetics as a discipline, genetic analysis as a tool to understand biology and the role of genome sciences in biology. Credit is not given for both MCB 317 and MCB 316. Prerequisite: MCB 250, MCB 251, MCB 252, and MCB 253; or consent of instructor.

MCB 320   Mechanisms of Human Disease   credit: 3 Hours.

The advent of molecular biology and the Human Genome Project has dramatically increased our understanding of the mechanisms of human disease. The underlying molecular causes for many diseases have been elucidated. This course examines how abnormalities that occur at the molecular and cellular level manifest as pathologies affecting the structure and function of human tissues and organs. In addition, this course focuses on the pathophysiology of common human diseases and the environmental, genetic and epigenetic causes of specific disease types. Prerequisite: MCB 252 or consent of instructor.

MCB 354   Biochem & Phys Basis of Life   credit: 3 Hours.

Introduction to biochemistry and structural biology emphasizing the physical and chemical properties of macromolecules. Credit is not given for both MCB 354 and MCB 450. Prerequisite: CHEM 232 or CHEM 236, and MCB 250 and MCB 252, or consent of instructor.

MCB 395   Special Topics in Human Physiology   credit: 2 Hours.

This course consists of 2 components: (1) a journal club, in which students explore current advances in the diagnosis, treatment, and understanding of human diseases by reading, presenting and discussing primary research articles; and (2) instructional support for MCB 244, in which students hold open office hours and make brief (10-15 minute) instructional videos that highlight advanced topics covered in journal club. Prerequisite: MCB 244 and MCB 246 and instructor approval.

MCB 396   Special Topics in Human Health and Disease   credit: 2 Hours.

This course consists of 2 components: (1) a journal club, in which students explore current advances in the diagnosis, treatment, and understanding of human diseases by reading, presenting and discussing primary research articles; and (2) instructional support for MCB 246, in which students hold open office hours and make brief (10-15 minute) instructional videos that highlight advanced topics covered in journal club. Prerequisite: MCB 244 and MCB 246 and instructor approval.

MCB 400   Cancer Cell Biology   credit: 3 Hours.

Principles of eukaryotic cell biology with an emphasis on cancer cell biology; consideration of molecular and fine structural components of the cell with an emphasis on experimental analysis of the relationship of structure to function of gene, membrane, cytoskeleton, and extracellular matrix. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 250, MCB 251, MCB 252, MCB 253, and credit or concurrent registration in MCB 354 or MCB 450 or consent of instructor.

MCB 401   Cell & Membrane Physiology   credit: 3 Hours.

Cellular and molecular basis of physiological process with an emphasis on phenomena taking place at the membrane of cells and organelles (e.g., signal transduction, ion transport, synaptic transmission, nerve conduction, bioelectricity, synaptic plasticity.) Structure and function of biological membranes through a quantitative lens. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 252 or consent of instructor.

MCB 402   Sys & Integrative Physiology   credit: 3 Hours.

Examines human systems physiology. Topics to be covered include the nervous and endocrine systems, muscle physiology, cardiac physiology, respiratory physiology, blood and immune homeostasis, renal physiology, and gastrointestinal physiology and energy homeostasis. Special emphasis is on homeostatic control and integration of body systems in both health and disease. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 252 or consent of instructor.

MCB 403   Cell & Membrane Physiology Lab   credit: 1 or 2 Hours.

Experimental investigation of cellular functions common to most eukaryotic cells; emphasis on biochemical, electrical, and mechanical recording techniques. Some animal dissection and the use of animal tissues are required in this course. Alternatives are not available. Inquiries concerning the use of or the dissection of animal tissues can be directed to the Instructor or Head of the Department. 2 undergraduate hours. 1 graduate hour. Prerequisite: Credit or concurrent registration in MCB 401 and previous biology laboratory experience.

MCB 404   Sys & Integrative Physiol Lab   credit: 1 to 2 Hours.

Experimental investigation of organ systems of vertebrates with emphasis on biochemical, electrical and physical recording techniques. Some animal dissection and the use of animal tissues are required in this course. Alternatives are not available. Inquiries concerning the use of, or the dissection of animal tissues can be directed to the instructor or Head of the Department. 2 undergraduate hours. 1 graduate hour. Prerequisite: Credit or concurrent registration in MCB 402 and previous biology laboratory experience.

MCB 406   Gene Expression & Regulation   credit: 3 Hours.

Provides in-depth and up-to-date coverage of gene expression and regulation. Lectures are centered on the principles of regulating gene expression in eukaryotic cells. The course covers macromolecule structure and function in gene expression; molecular mechanisms of the key gene expression events including transcription, RNA processing, localization and translation. Applications of these principles in medicine and therapeutics such as aging, cancer and drug design are also discussed. Same as BIOC 406. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 354 or consent of instructor.

MCB 408   Immunology   credit: 3 Hours.

Introduction to fundamentals of immunology with emphasis on biological application; basic background for understanding immunological responses and techniques applicable to biological research. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 250, MCB 251, MCB 252, MCB 253, and MCB 354; or consent of instructor.

MCB 410   Developmental Biology, Stem Cells and Regenerative Medicine   credit: 3 Hours.

Survey of molecular and cellular mechanisms involved in development and growth of animals, as well as recent advancement in stem cell and Regenerative medicine research. Topics to be covered include fertilization and early cell lineage, body axis formation, gastrulation, neural induction and patterning, segmentation, and other aspects of pattern formation including organogenesis and limb development, as well as embryonic stem cells, induced pluripotent stem cells, adult stem cells, regeneration and regenerative medicine. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 252 or consent of instructor.

MCB 413   Endocrinology   credit: 3 Hours.

Physiology and biochemistry of the endocrine system and its hormones with special reference to vertebrates and to human endocrine disorders. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 252 or consent of instructor. One semester of biochemistry is recommended.

MCB 419   Brain, Behavior & Info Process   credit: 3 Hours.

Exploration of the neural basis of animal behavior. Emphasis on the information processing problems that animals face in complex natural environments and how nervous systems have evolved to solve these problems. Introduction to the use of computer modeling and simulation techniques for exploring principles of nervous system design and function. Current literature in computational neurobiology and neuroethology will be incorporated in readings and class discussion. Same as BIOP 419 and NEUR 419. 3 undergraduate hours. 3 graduate hours. Prerequisite: CS 101; and PHYS 102 or PHYS 212; and MCB 252; or equivalent or consent of instructor.

MCB 421   Microbial Genetics   credit: 3 Hours.

Prokaryotic microbial genetic systems; emphasis on typical data analyses, together with the basic classes of genetic phenomena. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 300 or consent of instructor.

MCB 424   Microbial Biochemistry   credit: 3 Hours.

Examines the biochemical ecology of diverse microbial groups with emphasis on anaerobic systems. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 250 and MCB 354 or MCB 450, or consent of instructor.

MCB 426   Bacterial Pathogenesis   credit: 3 Hours.

Emphasizes prokaryotes that cause important diseases in humans and other animals; host-parasite bacteriology; and chemistry and genetics of mechanisms of pathogenesis. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 300 and MCB 354, or consent of instructor.

MCB 428   Microbial Pathogens Laboratory   credit: 2 Hours.

Laboratory study of methods of recognition and differentiation, diagnostic tests, and mechanisms of bacterial and viral pathogenesis. Topics include infections of the urinary tract, respiratory tract, gastrointestinal tract, and sexually transmitted diseases. 2 undergraduate hours. 2 graduate hours. Prerequisite: MCB 300 and MCB 301 or consent of instructor.

MCB 429   Cellular Microbiology &Disease   credit: 3 Hours.

Emphasizes cell biology of infectious diseases, using cellular, molecular, and animal models. Will stress molecular cross-talk that drives host-pathogen interactions, state-of-the art approaches for investigating host and microbial cell and molecular biology, latest paradigms in host cell biology, and, the evolutionary basis by which pathogens can manipulate host cell cytoskeleton, membranes, organelles, cell cycle, gene expression, and signaling in eukaryotic cells. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 300 and MCB 354 or consent of instructor.

MCB 430   Molecular Microbiology   credit: 3 Hours.

Modern contributions to the science of microbiology; emphasizes the structure, function, and synthesis of informational macromolecules and on the role microorganisms have played in molecular biology. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 300 and credit or concurrent registration in MCB 354, or consent of instructor.

MCB 431   Microbial Physiology   credit: 3 Hours.

Examines bacterial physiology, including discussions of energetics, regulation of metabolism, and cell structure. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 300 or equivalent; credit or concurrent registration in a biochemistry course.

MCB 432   Computing in Molecular Biology   credit: 3 Hours.

Examination of computational aspects of biology with an emphasis on the relationships between biological questions and their recastings as mathematical or logical problems. Topics are drawn from biochemistry, genetics, molecular sequence analysis, and molecular structure. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 250, MCB 252, MCB 354, and calculus I (MATH 220 or MATH 221), and calculus II (MATH 231) or biostatistics (STAT 212); or consent of instructor.

MCB 435   Evolution of Infectious Disease   credit: 3 Hours.

Understanding the evolution and ecology of the microbial world is of great importance to human health and the health of our planet. Students will explore the ecology and evolution principles that apply to viruses, microbial eukaryotes, archaea and bacteria. The primary literature on historical and emerging infectious diseases will be used to illustrate critical applications of these basic principles. Examples include applying genomics tools to understand the evolutionary basis for antibiotic resistance, the spread of emerging pathogens, and the ecology of probiotics and the human microbiome. The objective of this class is to better understand how humans shape the diversity and dynamics of the microbial world living in and around us every day. Same as IB 442. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 300 or consent of instructor.

MCB 436   Global Biosecurity   credit: 1 Hour.

Designed to provide students with broad coverage of key areas of scientific, legal, social, ethical, and political aspects of biosecurity, emphasizing current problems and research in the areas of biodefense, emerging infectious diseases, synthetic biology, and other topics. In combination with related reading assignments, the weekly special topics-based seminar will integrate knowledge of modern biomedical research, advances in biotechnology, and natural and manmade biological threats with the skills to analyze and develop public policies and strategies for enhancing global biosecurity. 1 undergraduate hour. 1 graduate hour. Prerequisite: MCB 150 or the equivalent or consent of instructor.

MCB 450   Introductory Biochemistry   credit: 3 Hours.

Chemistry and metabolism of carbohydrates, lipids, proteins, nucleic acids, vitamins, and coenzymes and their relation to the regulation and processes of organisms, cells, and subcellular components. Students who enter the University Fall 2011 or later are responsible for additional course-based tuition of $300 unless they are already paying differential tuition during the term of course enrollment. Additional fees may apply. See Class Schedule. 3 undergraduate hours. 3 graduate hours. Credit is not given for both MCB 450 and MCB 354. Prerequisite: CHEM 232 or CHEM 236, or equivalent, or consent of instructor. Not intended for students in the MCB or biochemistry curricula.

MCB 458   Basic Human Pathology   credit: 3 Hours.

Introduction to the basic mechanisms of human disease with a focus on the building blocks of pathological processes at the sub-organismal and organismal level. Basic biological processes will be stressed including tissue adaptation, injury, inflammation, repair and neoplasia. Pathology synthesizes cellular and molecular biology, biochemistry and immunology holistically so as to understand the body's limited responses to the cornucopia of experienced physiological insults. 3 undergraduate hours. No graduate credit. Prerequisite: MCB 354 or equivalent, or consent of instructor. For MCB and Biochemistry undergraduate majors only.

MCB 460   Regeneration and Medicine   credit: 3 Hours.

A survey of regeneration biology and medicine at the organ, tissues, and cellular/genetic/molecular/levels. Basic concepts are presented with a focus on contemporary methods and seminal experiments. Students will learn to think critically and creatively about experimentation and analyses of three regenerative medicine strategies: stem cell transplantation, bioartificial tissues, and chemical induction of regeneration in vivo. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 410 or consent of instructor. Recommended: knowledge of vertebrate histology and anatomy.

MCB 461   Cell & Molecular Neuroscience   credit: 3 Hours.

Designed as an in-depth foundation course for graduate and undergraduate students with strong neuroscience interests. Covers up-to-date cellular and molecular neurobiology (including basic principles of neuronal function, signaling, and plasticity) and introductory brain anatomy that underlie brain function and animal behaviors. Pathogenic mechanisms of neurological diseases and disorders from the latest research will be heavily explored. Same as NEUR 461. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 252, MCB 250 or equivalent, or consent of instructor. May be taken concurrently with MCB 462.

MCB 462   Integrative Neuroscience   credit: 3 Hours.

Employs integrative, multi-level systems approaches to nervous system and behavior. Focuses on neural circuits in sensory integration, pattern generation, the integration of sensation, internal states and learning in behavioral decision, the neuronal natures of pain, sleep, and biological rhythms, neuroeconomics, new vistas in neural modeling and interfacing brain and machine. Students are presented in neuroethological contexts of evolution and the economics of behavior and physiology. Same as NEUR 462. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 252 or consent of instructor. May be taken concurrently with MCB 461.

MCB 465   Human Metabolic Disease   credit: 3 Hours.

Examination of the molecular and physiological basis of human metabolic disease. Disruption of metabolic and energy homeostasis plays key roles leading to metabolic disorders. We will examine how lipid/glucose levels and energy balance are controlled in health and how they are abnormally regulated in disease sates. In addition, we will cover current topics related to control of metabolism including aging and circadian rhythms. Methodologies leading to scientific discoveries and potential preventive and therapeutic agents will also be discussed. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 250, MCB 252, or consent of instructor.

MCB 471   Cell Structure and Dynamics   credit: 3 Hours.

Molecular basis of cellular organization focusing on how cells secrete, move, adhere, divide, communicate, and die. Material will emphasize critical analysis of experiments, current controversies and hypothesis testing. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 250 and MCB 252 or consent of instructor. Prior or concurrent enrollment in MCB 354 desirable.

MCB 480   Eukaryotic Cell Signaling   credit: 2 Hours.

General principles of molecular signaling regulating membrane, cytoplasmic, and nuclear events in eukaryotic cells with emphasis on mammalian systems. Contemporary methods of investigation and the principles of identifying and solving problems related to signal transduction will be emphasized. 2 undergraduate hours. 2 graduate hours. Prerequisite: MCB 252 or consent of instructor.

MCB 481   Developmental Neurobiology   credit: 3 Hours.

Principles of vertebrate and invertebrate developmental neurobiology with emphasis on the molecular and cellular mechanisms controlling neuronal determination, axon pathfinding, synapse formation, and plasticity. Same as NEUR 481. 3 undergraduate hours. 3 graduate hours. Prerequisite: MCB 400 or MCB 461 or consent of instructor.

MCB 492   Senior Thesis   credit: 3 to 5 Hours.

Research conducted under the direction of a faculty member in the School of Molecular and Cellular Biology. Normally, the student enrolls in MCB 492 during the last semester on campus prior to graduation. In the semester preceding enrollment, interested students should consult with their faculty advisors concerning enrollment procedures. A minimum of 3 credit hours is required, and a thesis must be presented for credit to be received. Successful completion of MCB 492 is required in order to be eligible for graduation with distinction in MCB. 3 to 5 undergraduate hours. No graduate credit. Prerequisite: Two consecutive semesters of at least 2 credit hours of MCB 290 under the guidance of the same faculty member, or consent of instructor.

MCB 493   Special Topics Mol Cell Biol   credit: 1 to 4 Hours.

Discussion of current topics of interest within the broad domain of molecular and cellular biology; seminar or lecture format. Topics vary. May be repeated to a maximum of 12 hours. Prerequisite: Junior standing and consent of instructor.

MCB 501   Advanced Biochemistry   credit: 4 Hours.

Focuses upon structure-function analyses of biomolecules and the chemical and evolutionary foundations of metabolic networks. Emphasis is on research methodology and current problems.

MCB 502   Advanced Molecular Genetics   credit: 4 Hours.

An advanced course in molecular genetics. Emphasis is on research methodology and current problems.

MCB 509   Curr Topics Mol & Int Physiol   credit: 2 Hours.

Advanced seminars in current physiological research. May be repeated once for credit. Prerequisite: Consent of instructor.

MCB 512   Advanced Endocrinology   credit: 2 Hours.

Seminars, lectures, student reports, and discussions of recent advances in endocrinology. Same as ANSC 530 and CB 512. May be repeated to a maximum of 8 hours. Prerequisite: Consent of instructor.

MCB 513   Survey of Neurobiology   credit: 1 Hour.

Overview of the functional and organizational principles of the mammalian nervous system. Intended for graduate students with little or no prior coursework in neurobiology. Students will read and discuss current scientific papers from the neurobiological literature. Same as NEUR 513.

MCB 520   Advanced Molecular Biology   credit: 1 Hour.

Advanced graduate level, primary literature-based discussion course on molecular microbiology. Graduate level companion course for MCB 430. Prerequisite: Concurrent registration in MCB 430 or consent of instructor.

MCB 521   Advanced Microbial Genetics   credit: 1 Hour.

Advanced level, primary literature-based discussion course on microbial genetics. Graduate level companion course for MCB 421. Prerequisite: Concurrent or prior enrollment in MCB 421 or consent of instructor.

MCB 526   Adv Bacterial Pathogenesis   credit: 1 Hour.

Advanced primary literature-based discussion course on bacterial pathogenesis. Graduate level companion course for MCB 426. Prerequisite: Concurrent or prior enrollment in MCB 426 or consent of instructor.

MCB 529   Special Topics Cell Devel Biol   credit: 1 to 4 Hours.

Discussion of current topics of interest in higher eukaryotic cellular and molecular biology, development, neurobiology; seminar or lecture format. Topics vary. May be repeated to a maximum of 8 hours. Prerequisite: Consent of instructor.

MCB 530   Reproductive Physiol Seminar   credit: 1 Hour.

Presentation and discussion of current literature as well as graduate student and staff research proposals and findings in reproductive physiology. May be repeated to a maximum of 4 hours. Prerequisite: Consent of instructor.

MCB 532   Advanced Microbial Physiology   credit: 1 Hour.

Advanced primary literature-based discussion course on microbial physiology. Graduate level companion course for MCB 431. Prerequisite: Concurrent or prior registration in MCB 431 or consent of instructor.

MCB 534   Advanced Microbial Metabolism   credit: 1 Hour.

Advanced primary literature-based discussion course on microbial metabolism. Graduate level companion course for MCB 424. Prerequisite: Concurrent or prior enrollment in MCB 424 or consent of instructor.

MCB 539   Advanced Cellular Microbiology   credit: 1 Hour.

Advanced primary literature-based discussion course on cellular microbiology and underlying infectious diseases. Graduate level companion course for MCB 429. Prerequisite: Concurrent or prior enrollment in MCB 429 or consent of instructor.

MCB 540   Scientific Writing   credit: 3 Hours.

Study of scientific communication, geared toward biologists. Topics include writing mechanics, grammar and sentence structure, abstracts for different audiences and purposes, grant writing, manuscript preparation, figure construction, oral presentations, and the grant-review process. Class consists of both lectures and time working in small groups to revise writing assignments. Assignments include weekly writing exercises, a full NIH-style grant proposal and grant reviews for a mock study section. 2 graduate hours. No professional credit.

MCB 545   Functional Genomics in Principle and Practice   credit: 3 Hours.

Experimental and analytical foundations of functional genomics, tailored to experimental biologists who are using high-throughput sequencing technologies to analyze function in animal genomes. Lectures cover experimental methods and tools available for bioinformatics analysis; students will gain experience in the use of online or command-line bioinformatics tools through weekly assignments. Advanced knowledge in eukaryotic molecular genetics is needed but bioinformatics skills are not required. 3 graduate hours. No professional credit. Students must have access to a networked computer on which they can load software in order to complete required assignments for the course. Prerequisite: MCB 502 or equivalent or consent of instructor.

MCB 555   Anlys Biochemical Literature   credit: 2 Hours.

Discussions of current research and literature. Required of all graduate students whose major is biochemistry. Same as BIOC 555. Prerequisite: Second year graduate standing in biochemistry or consent of instructor.

MCB 580   Res Ethics & Responsibilities   credit: 1 Hour.

Lecture/discussion course focusing on research ethics and a variety of related issues that can influence success in graduate school in the biological sciences, including scientific integrity and compliance with regulations for laboratory research. Approved for letter and S/U grading. Prerequisite: Consent of instructor.

MCB 581   Laboratory Rotation I   credit: 3 Hours.

Laboratory research methods; familiarization of first-year graduate students with experimental methods used in molecular and cellular biology research. Required of all first-year students entering MCB. Meets first five weeks of each term. Approved for S/U grading only. Prerequisite: First-year graduate status and consent of MCB graduate programs; concurrent registration in MCB 582.

MCB 582   Laboratory Rotation II   credit: 3 Hours.

Laboratory research methods; familiarization of first-year graduate students with experimental methods used in molecular and cellular biology research. Required of all first-year students entering MCB. Meets second five weeks of each term. Approved for S/U grading only. Prerequisite: First-year graduate status and consent of MCB graduate programs; concurrent registration in MCB 581.

MCB 583   Laboratory Rotation III   credit: 3 Hours.

Laboratory research methods; familiarization of first-year graduate students with experimental methods used in molecular and cellular biology research. Required of all first-year students entering MCB. Meets third five weeks of each term. Approved for S/U grading only. Prerequisite: First-year graduate status and consent of MCB graduate programs; concurrent registration in MCB 581 and MCB 582.

MCB 585   Current Topics in Microbiology   credit: 1 Hour.

Discussions, reviews, and appraisal of special topics in microbiology and molecular biology; seminar or lecture. Topics vary. Approved for S/U grading only. May be repeated to a maximum of 8 hours. Prerequisite: Consent of instructor.

MCB 595   MCB Graduate Seminar   credit: 1 Hour.

Advanced seminars on current topics of interest in molecular and cellular biology. Approved for S/U grading only. May be repeated in separate terms to a maximum of 4 hours. Prerequisite: Consent of instructor.